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No one really knows what causes Dupuytren’s contracture, but it is well known that it runs in families-60 to 70% of individuals have a family history of the disease.

Other factors have been suspected, such as trauma, diabetes, alcoholism, epilepsy, and liver disease, but there is no clear relationship. The disease in most common in older (usually after age 40) men (about 10 times more often than women) with North European ancestry (one group commonly cited is those with Viking ancestry).

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