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How To Perform an Injection Into the Knee


Updated April 23, 2014

How To Perform an Injection Into the Knee

Knee Injection

Photo (c) iStockphoto.com
Knee injections are commonly performed both to remove swelling (effusions) and to place medication (such as Synvisc and cortisone) into the knee. How is an injection performed?
Difficulty: Average
Time Required: 5 minutes

Here's How:

  1. Determine if an injection is appropriate
    First and foremost, your doctor must discuss your condition and what treatments are appropriate. Not all conditions are appropriately treated with injections. Your doctor can discuss the cause of your knee pain and what treatments are available.

  2. Obtain the proper medication
    Most orthopedic surgeons have cortisone stored in the office. Hyaluronic acid (e.g. Synvisc, Orthovisc, etc.) often are not stored in your doctor's office, and usually require insurance preapproval. Therefore, these medications may need to be obtained prior to an injection appointment.

  3. Sterilize the skin
    Once an injection is planned, the steps to carry out the procedure may begin. The skin must be properly sterilized to minimize the chance of infection. Infection of the joint is the most concerning side-effect of injections. This is a very rare complication, but it is possible. Sterilizing the skin with Betadine and/or alcohol can help to decrease (although not eliminate) the risk of infection.

  4. Numb the skin (optional)
    Topical numbing sprays are often sufficient to dull the pain associated with an injection. When simply injecting the knee (and not removing fluid), a small needle can be used to inject medication. When a joint aspiration is necessary to remove fluid from the knee, a larger needle must be used. In these cases, some patients may find relief if a small amount of Lidocaine (Novocaine) is injected into the skin prior to the aspiration.

  5. Insert the needle into the knee joint
    A needle is then inserted into the joint to inject the medication or remove the swelling from the knee. Studies have shown that the most reliable place to inject the knee is with the patient lying flat and the knee straight, and the needle placed from the outside, under the kneecap. Other injection sites may also be used.

  6. Remove excess fluid from the knee
    If the joint is swollen (a so-called "knee effusion"), the excess fluid should be removed prior to injecting medication. Excess fluid in a joint may dilute the medication making the treatment less effective. Furthermore, knee swelling is associated with pain, and removing the excess fluid can lead to pain relief.

  7. Inject the medication
    The medication is then injected into the knee. The amount of medication injected depends on the treatment. Most types of hyaluronic acid (e.g. Synvisc, Orthovisc) are 2 cc. Cortisone injections vary depending on surgeon preference, and are often injected simultaneously with Novocaine.

  8. Place pressure on the injection site, and bend the knee
    Once the injection is performed, gentile pressure over the injection site will prevent bleeding, and bending the knee can help circulate the medication.

  9. Apply an ice pack if pain persists
    Most often injections do not slow down your lifestyle. Some patients may experience a "flare up" of the knee after the injection. Usually a simple ice pack placed on the knee can help to alleviate this pain.


  1. Let your doctor know if you are nervous
    If you are concerned about any aspect of the injection, let your doctor know. Often knowing what is coming, and understanding the procedure, will help put you at ease.

    If you are nervous about pain, ask your doctor to use a topical anesthetic.

    Most orthopedic surgeons perform several injections every day. Let your doctor know if you are nervous--your doctor may not know if you are having anxiety!

  2. Watch for signs of infection
    As mentioned, infections are the most worrisome complication of knee injections. Let your doctor know if you have:
    • Worsening swelling or pain
    • Redness of the knee
    • Drainage from the injection site
    • Fevers, chills, or sweats
    • Any other concerning symptoms
Related Video
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  1. About.com
  2. Health
  3. Orthopedics
  4. Hip & Knee
  5. Treatments
  6. Injections
  7. How to Perform a Knee Injection for Medication

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